Hits: 370

This is a thread on use of drugs for COVID19

Hydroxychloroquine (Lupus, RA) Lopinavir/Ritonavir (HIV/AIDS) Remdisivir and Favipiravir (Ebola) and Camostat (Pancreatitis, Japan) are drugs that seem to have activity against SARSCov2 Some of these are used on Emergency Basis. Hydroxychloroquine is widely used for Rheumatoid Arthritis and Lups with good safety margin. It is similar to chloroquine without antimalarial activity. It is also safer than Chloroquine. It inhibits many enveloped viruses including Coronavirus and Ebola. Hydroxychloroquine has superior activity against coronavirus compared to Chloroquine in concentrations achievable in practice. 400 mg Twice Daily for 1 day 400m daily for 6 days 5-6 mg/day maintenance would be sufficient. Although there are no trials proving Hydroxychloroquine efficacy, it is being used where no other treatments are available for prophylaxis among medical personnel.

Side effects:

Use of Hydroxychloroquine at bedtime reduces common side effects. Retinal toxicity on long term use occurs when maintenance dose of >6mg more than 4 years. Unlikely <5mgkg (actual weight) Corneal toxicity (reversible) seen with chlroroquine are rare with hhdroxychloroquine. Favipiravir is an antiviral drug developed for Ebola that has been shown to be active against COVID19 SARSCov2 in China.

Here is a review of drugs with activity against SARSCov2 And Remdisivir developed by Gilead against Ebola tops the list Anecodotal social media news also supports efficacy (awaiting actual results).

Here is another review that lists all drugs that have some activity against the coronavirus #COVID19 #SARSCov2 Not surprisingly CyclosporinA is in the list (Many viruses need Cyclophilins for hijacking the cells). Discovering Drugs to Treat Coronavirus Disease 2019 (COVID-19)

A detailed review on the prospects of nucleoside drugs against respiratory viruses. Nucleosides for the Treatment of Respiratory RNA Virus Infections

Dr Able Lawence (link)